From signals to sales: 6 powerful signals that drive results with Amplemarket AI agents

You never get a second chance to make a first impression and when it comes to sales outreach, timing and relevance are everything.

The industry average response rate is disappointingly low, but what if you could consistently generate higher-quality conversations with less effort?

That's exactly what top performers achieve using Amplemarket's Duo Copilot, a suite of AI agents built for signal-based selling.

What you'll learn in this guide

In this comprehensive guide, we'll walk you through:

• The 6 highest-converting buying signals
• Ready-to-use prompts for each signal
• Sample message templates to drive responses
• Sequence structures that maximize engagement
• Messaging best practices
• Words and phrases to avoid that kill your response rates

By the end, you'll have everything you need to implement signal-based selling and dramatically improve your outreach results.

Stick with me for the next few minutes, and I'll show you how to leverage Duo's most powerful signals to connect with prospects at exactly the right moment.

Why signal-based selling is your secret weapon

Let's face it, traditional outreach is tough. Your prospects' inboxes are overflowing, and generic pitches get ignored faster than you can say "just checking in."

But what if you could reach out at the exact moment a prospect shows buying intent? That's the magic of signal-based selling with Duo.

Wondering what Duo is?

Think of Duo as your team of specialized AI agents working behind the scenes:

• Research Agent: Continuously scans the web for buying signals and prospect intelligence
• Insights Agent: Provides recommendations to help you optimize your approach
• Engagement Agent: Crafts personalized multichannel outreach based on the specific signal detected

While Duo handles the heavy lifting, you maintain full control to tweak and refine your sequences for maximum impact.

Now let's dive into the signals that are generating incredible results for sales teams right now.

Note: For each signal, Duo automatically generates a multichannel outreach sequence along with an editable prompt you can adjust to fit your voice and strategy.

1. Posts From Your Company

What’s the signal & why it matters:

When someone engages with your company's content on LinkedIn, they're raising their hand and saying, “Hey, I'm interested in what you're talking about.” This creates a natural opening that doesn’t feel like cold outreach at all.

How Duo helps:

Duo continuously monitors and tracks relevant signals and prospect activities, providing you with up-to-date insights and context. Based on this intelligence, it automatically generates personalized outreach tailored to the specific type of interaction, helping you engage leads by referencing their unique engagement with your company’s posts.

Prompt Duo shares:

Engage with the lead by showing curiosity about their interaction with a post from my company on LinkedIn. Don't mention the type of interaction if it’s not a comment (e.g., instead of saying “I noticed you liked” say “I came across your interaction”). If the interaction is a comment, make sure to mention it (e.g., say “Saw you commented”). If the post is from me, make sure to mention that. If the post is from a person from my company, make sure to mention that they are a colleague of mine.

What Duo generates:

Subject line: Saw your interaction

Hi {{first_name}},

I came across your interaction with {{original_poster}}'s post about [industry-specific topic]. It got me thinking about how {{company_name}} might be looking to enhance its [relevant business area].

At [Your Company], we help teams like yours by providing tools to generate high-quality leads effortlessly and build authentic relationships with prospects. Our platform uses AI to monitor relevant signals and create personalized outreach sequences, saving you hours on research and personalization.

Is this worth exploring for {{company_name}}?

2. Past Customer Job Changes

What’s the signal & why it matters:

This is the golden ticket of signals. When someone who used your product at their previous company moves to a new role, they're already familiar with your value. They can become your internal champion without the typical education process.

How Duo helps:

Duo continuously monitors job changes and prospect activity, tracking when past customers move to new roles. It provides actionable insights to engage them thoughtfully and then automatically generates personalized outreach that acknowledges their transition and suggests bringing your product along for their new journey.

Prompt Duo shares:

Engage with the lead on the basis that they have recently changed jobs and the company where they were previously at is a current customer of ours. There is a good chance they will be interested in using our product at their new company. Engage with them by acknowledging their recent transition and asking, given that they are a recent past user of our product, if this might be a good opportunity to bring it along for their new journey/challenge, if they see a potential fit at the new company.

What Duo generates:

Subject line: This made me curious

Hi {{first_name}},

Noticed your recent transition to {{new_company}} and thought it might be a good opportunity to bring along the AI-driven insights and multichannel engagement that you experienced at {{previous_company}}.

[Your Company]'s AI-powered platform can help you identify ready-to-buy prospects and personalize your outreach at scale. Could this be something that aligns with your goals at {{new_company}}?

Interested to know your thoughts.

3. Closed Lost Reactivation

What’s the signal & why it matters:

Just because a deal didn’t close previously doesn’t mean it’s gone forever. Circumstances change, budgets get approved, and competitors disappoint. Reaching out at the right time can revive these opportunities.

How Duo helps:

Duo keeps track of past lost deals and related details, providing insights into previous interactions and reasons for loss. It then automatically crafts respectful, personalized outreach aimed at reigniting the conversation and exploring if needs have evolved.

Prompt Duo shares:

Engage with the lead based on the fact that they were previously involved in a deal or conversation with us that ended in a closed-lost stage. Use opportunity context fields to reference relevant past details (goals, challenges) or reasons for loss (competitor, budget, timing). The goal is to reignite the conversation by asking how their situation has evolved since our last touchpoint, mentioning our last touchpoint as the reason for outreach. Stay courteous and respectful; focus on rekindling the relationship.

What Duo generates:

Subject line: Reconnecting

Hi {{first_name}},

I remember we had some discussions about [Your Company] a while back, but it seems we couldn't align our schedules. I'm curious to know if your needs have shifted since then.
We recently launched [Your AI Sales Copilot], which might be relevant for your team at {{company_name}}. 

It helps streamline outreach and provides unique insights.
Has your team found a solution that meets your expectations, or are you still exploring options?

4. Followers of Your Company

What’s the signal & why it matters:

When someone follows your company on LinkedIn, they're expressing direct interest in what you do. This is a clear sign that they may be exploring solutions relevant to their challenges.

How Duo helps:

Duo tracks new followers and monitors their activity to provide you with context. It then automatically generates outreach referencing their recent follow action, opening a conversation about potential needs without feeling intrusive.

Prompt Duo shares:

Engage with the lead based on the fact that we saw they've started following our company on LinkedIn recently. Be tentative about how they might be looking for new solutions for their team’s challenges.

What Duo generates:

Subject line: Following [Your Company]?

Hi {{first_name}},

I noticed you recently started following [Your Company] on LinkedIn. It got me curious if you might be exploring new solutions for your team at {{company_name}}.

[Your AI Sales Copilot] could help you uncover opportunities and grow revenue with AI. It monitors the web for relevant signals and builds personalized multichannel sequences, freeing up your team to focus on closing deals.

Would this be worth exploring for your team?

5. Posts Mentioning Specific Keywords

What’s the signal & why it matters:

When prospects engage with content containing keywords relevant to your solution, they’re signaling interest in topics you can help with. It’s like raising their hand in a crowded room saying, "I care about this issue."

How Duo helps:

Duo monitors keywords across LinkedIn and other channels, tracking interactions related to those keywords. It leverages this intelligence to craft messages that align carefully with the prospect’s interests and challenges, without overpromising.

Prompt Duo shares:

Engage with the lead by showing curiosity about their interaction with a post on LinkedIn. If the interaction is a comment, mention it. Mention if the lead or I am the original poster. If the post doesn’t present a challenge targeted by my value propositions, never claim we can solve it. Be tentative and assume a challenge.

What Duo generates:

Subject line: saw your comment on [keyword]

Hi {{first_name}},

Saw your comment on the post about [keyword]. It struck me that your team at {{company_name}} might be exploring ways to address this challenge.

At [Your Company], we use AI to find opportunities and personalize outreach to help teams like yours build pipeline faster.

Would you be open to a brief chat to explore if this fits your current priorities?

6. Active Engagement on Competitor Content

What’s the signal & why it matters:

When prospects actively engage with competitor content, it means they're likely in the market and researching alternatives. This is your chance to demonstrate how you stand out.

How Duo helps:

Duo monitors competitor content engagement and flags relevant interactions. It then crafts outreach that highlights your differentiators based on competitor pain points and prospects’ activities.

Prompt Duo shares:

Engage with the lead who has engaged with competitor content. Highlight your unique advantages in a subtle and respectful way. Don’t attack competitors directly; focus on benefits.

What Duo generates:

Subject line: Noticed your interest in [competitor]

Hi {{first_name}},

Noticed your engagement with [competitor] content recently. Thought it might be a good time to share how [Your Company] offers a unique approach that could better meet your needs.

Our AI-driven platform helps sales teams identify high-intent prospects and personalize outreach at scale — saving time and increasing conversions.

Would you be open to a quick discussion?

The Secret Sauce: Sequence structure that converts

The signals above are powerful, but they're even more effective when delivered through the right sequence structure. Here's what's working right now:

For 1st degree connections:

1. Profile Visit
2. LinkedIn Message
3. Profile Visit
4. AI Voice Message — Introduction
5. AI Voice Message — Social Proof
6. Like a Post
7. Follow-up Text Message
8. LinkedIn Profile Visit

For non-connections:

1. Email
2. Email with Social Proof
3. Call Step
4. Breakup Email

This multichannel approach ensures maximum visibility across different touch points.

Crafting messages that get responses

Want to make your Duo-generated messages even more effective? Here are the messaging best practices that top performers swear by:

Tone of voice that converts

• Keep subject lines short (under 5 words) and lowercase
• Sound like a human, not a robot or corporation
• Be casual yet professional to build trust
• Avoid exclamation points and overeager language
• Skip generic phrases like "impressive background" or "leaders like yourself"
• Abbreviate company names when appropriate (e.g., "Lumen" instead of "Lumen Energy")

Structure that gets read

• One call to action per message, placed at the end as a question
• Short paragraphs with plenty of white space
• 6th-7th grade reading level with simple words
• Varied content across channels (don't repeat the same customer story)
• No references to previous outreach attempts
• No bullet points or complicated formatting

Words and phrases to avoid

• "Are you in?" or "are you in?"
• "I believe" or "I think" when highlighting how we could help
• "Impressive background" or "I saw" or "I noticed"
• "Tools" or "solutions" or "challenges" or "product"
• "Congrats on the new role"
• "Noticed your interest"
• Any reference to their title/role or phrases like "as a leader"

Ready to transform your outreach?

Signal-based selling with Amplemarket's Duo Copilot isn't just another sales tactic, it's a complete paradigm shift in how you approach prospecting.

By focusing on prospects who have already shown interest through their actions, you can:

• Reach out at the perfect moment when prospects are most receptive
• Craft messages that feel relevant and timely, not random and intrusive
• Save countless hours on manual research and personalization
• Consistently achieve response rates much higher than industry averages

The signals, prompts, and messaging guidelines in this guide represent what's working right now for top-performing sales teams. Implement them with Amplemarket's AI Sales Copilot, and watch your response rates soar.

Start your free trial today to know more.